Avanafil Dosage: How Much to Take, When to Adjust, and What to Avoid

When you're looking at Avanafil, a fast-acting PDE5 inhibitor used to treat erectile dysfunction. Also known as Stendra, it works by increasing blood flow to the penis, helping you get and keep an erection when sexually stimulated. Unlike some older ED meds, Avanafil starts working in as little as 15 minutes, which is why many men choose it for spontaneous intimacy.

Most people start with a 100 mg dose taken about 30 minutes before sex. That’s the sweet spot for most — effective without being too strong. But if you’re over 65, have liver problems, or take certain medications like ketoconazole or ritonavir, your doctor might start you at 50 mg. Don’t up the dose on your own. Going above 200 mg doesn’t give better results — it just raises your risk of side effects like headaches, flushing, or dizziness. And never mix Avanafil with nitrates. That combo can drop your blood pressure to dangerous levels. It’s not just a warning — it’s a life-saving rule.

Avanafil isn’t the only PDE5 inhibitor out there, but it’s one of the fastest. Compare it to sildenafil, the active ingredient in Viagra, which usually takes 30 to 60 minutes to kick in, or tadalafil, the long-lasting option in Cialis, which can work for up to 36 hours. Avanafil sits in the middle — quick, reliable, and gone in about 6 hours. That’s good if you don’t want a drug lingering in your system. But it also means timing matters. Take it on an empty stomach or with a light meal. A heavy, fatty meal can delay how fast it works.

People often wonder if they can split pills or take Avanafil daily. The answer is no — it’s not approved for daily use. Stick to once a day, max. And if it doesn’t work after a few tries, don’t assume the dose is too low. Sometimes the issue isn’t the drug — it’s stress, low testosterone, or something else. Talk to your doctor. They might check your hormone levels or suggest combining it with lifestyle changes like weight loss or quitting smoking. Those steps can make Avanafil work better than just upping the dose.

What you’ll find in the posts below are real, practical answers to the questions most people don’t ask out loud. How does Avanafil compare to other ED pills when you’re on blood pressure meds? Can you take it with alcohol? What happens if you accidentally take two? You’ll also see how it stacks up against other treatments, what side effects actually matter, and how to avoid the most common mistakes that lead to wasted money and frustration. This isn’t theory. It’s what works — and what doesn’t — for real people using Avanafil every day.