Methotrexate (MTX) is a prescription medicine used for several conditions. Doctors prescribe low weekly doses for rheumatoid arthritis, psoriasis, and some autoimmune diseases. Much higher doses are used in chemotherapy, but those are given in hospitals. MTX slows the immune system and lowers inflammation, which helps control symptoms and prevent long-term damage.
For autoimmune conditions the usual plan is a single low dose taken once a week. That once-a-week timing is critical. People who accidentally take daily doses can get serious toxicity. Tablets and injections are both common. Your doctor will pick the route and dose based on your illness, weight, and other medicines.
Folic acid is often given alongside methotrexate to cut down on side effects like mouth sores, nausea, and low blood counts. Clinical guidelines and trials show folic acid reduces these side effects without hurting treatment effect. Don’t stop the folic acid unless your doctor tells you to.
MTX can affect the liver, bone marrow, and lungs. That’s why doctors order regular blood tests—liver enzymes and blood counts—especially during the first months. If you drink alcohol regularly, talk to your doctor. Many clinicians recommend limiting alcohol because it raises the risk of liver damage.
Common side effects include nausea, fatigue, and mouth ulcers. Less common but serious problems are severe infections, liver damage, and lung inflammation. If you have new shortness of breath, persistent cough, unexplained bruising, bleeding, or fever, contact your doctor right away.
MTX is dangerous in pregnancy. Men and women should use reliable contraception while on treatment and for a period after stopping, as advised by the prescriber. Don’t breastfeed while taking methotrexate unless your doctor says it’s safe.
Drug interactions matter. NSAIDs, some antibiotics, and other drugs can raise MTX levels and increase risk. Always tell every clinician and pharmacist that you take methotrexate.
Before starting MTX mention liver disease, heavy alcohol use, active infection, and planned vaccines. Live vaccines aren’t recommended while on methotrexate.
If you miss a weekly dose, follow your prescriber’s instructions—don’t double up to catch up unless told to do so.
How to buy methotrexate safely: only use licensed pharmacies and never order prescription-only drugs from sites that don’t require a prescription. Check for pharmacy accreditation, clear contact details, and secure payment. Rogue sellers may send incorrect or unsafe products. If you’re importing medication, check local rules and customs to avoid seizures or legal trouble.
Keep all medical appointments and lab tests while on MTX. It works well for many people when used correctly. Ask questions, keep notes on side effects, and get a clear plan from your prescriber about dosing, monitoring, and contraception.
Prednisone packs a punch for autoimmune disorder relief, but the side effects are rough. Here’s a no-nonsense look at real alternatives like budesonide, methotrexate, and biologics so you can weigh your options smartly.
CONTINUE
