Allopurinol Cost: What You Really Pay and Where to Save

When you’re managing gout or high uric acid levels, allopurinol, a xanthine oxidase inhibitor used to lower uric acid in the blood. Also known as Zyloprim, it’s one of the most common long-term treatments for preventing gout attacks. But if you’ve checked the price at your local pharmacy, you know it can feel like a shock—especially if you’re paying full retail. The good news? Allopurinol is a generic drug, and its cost can drop by over 90% depending on where you buy it and how you pay.

The uric acid reducer, a class of medications that block the production of uric acid works by stopping your body from making too much of it. That’s why doctors prescribe it for people with frequent gout flare-ups, kidney stones caused by uric acid, or those on chemotherapy. But the real question isn’t how it works—it’s how much it costs. In the U.S., brand-name Zyloprim can run $100+ for a 30-day supply. Meanwhile, generic allopurinol? You can find it for under $10 at many online pharmacies, and even less with discount cards. Prices vary wildly because pharmacies set their own rates, insurance plans have different tiers, and some sellers mark up generics just because they can.

Don’t assume your local pharmacy has the best deal. Many people don’t realize that buying generic allopurinol from trusted international online pharmacies can cut costs in half or more—without changing the quality. It’s the same active ingredient, same manufacturer standards, same FDA or equivalent regulatory oversight. The difference? Lower overhead, fewer middlemen, and direct sourcing. You’ll also find that dosage matters. A 100mg tablet is cheaper per pill than a 300mg one if you’re splitting doses, and buying in bulk often brings the price down further.

What you won’t find in most doctor’s offices is a clear breakdown of these options. Most providers focus on prescribing, not pricing. That’s why you’re here. Below, you’ll find real-world comparisons of allopurinol prices, tips to avoid overpaying, and insights into how it stacks up against other gout meds in terms of cost and effectiveness. Some posts cover how it interacts with alcohol or kidney function. Others compare it to febuxostat or probenecid—not just in how they work, but how much they cost. You’ll see what people actually pay, not what’s listed on a price tag. No fluff. Just what you need to save money and stay on track with your treatment.